Syllabus For The Subject SYSTEM BIOLOGY

UNIT - 01

INTRODUCTION TO SYSTEMS BIOLOGY WHAT IS SYSTEMS BIOLOGY? INTEGRATING

NETWORKS -

METHODS OF STUDY - MICRO ARRAY - DEFINITION - TYPES OF ARRAY

UNIT - 02

MICRO ARRAY ANALYSIS

UNIT - 03

HIERARCHICAL CLUSTERING - SELF-ORGANIZING MAPS - APPLICATIONS OF MICRO

ARRAYS IN SYSTEMS BIOLOGY

UNIT - 04

METABOLISM & METABOLIC PATHWAYS - DIGESTION OF PROTEINS AND PROTEIN

METABOLISM - TRANSPORT METABOLISM

UNIT - 05

CARBOHYDRATE - METABOLISM - METABOLISM OF GLUCOSE - GLYCOLYSIS - TCA

CYCLE - GLYCOGENESIS

UNIT - 06

PENTOSE PHOSPHATE SHUNT - ELECTRON TRANSPORT - INTERCONNECTION OF

PATHWAYS -METABOLIC REGULATION - TRANSLATING BIOCHEMICAL NETWORKS INTO

LINEAR ALGEBRA

UNIT - 07

WHOLE CELL SIMULATION: PRINCIPLE AND LEVELS OF SIMULATION - VIRTUAL

ERYTHROCYTES, PATHOLOGICAL ANALYSIS.

UNIT - 08

FLUX BALANCE ANALYSIS - RELATIONSHIP ANALYSIS - PREDICTING LEGEND - BINDING

FUNCTION - USE OF GENE CLUSTER- DETECTING PROTEIN - PROTEIN INTERACTION

UNIT - 09

CREATIVE BIOINFORMATICS - NOVEL USE FOR DATABASE - USE OF EST DATABASE

UNIT - 10

UNIGENE - GENE DISCOVERY - PRIMER DESIGN - RESTRICTION MAPPING

UNIT - 11

POSITION SPECIFIC CLONING - SNP DATABASE - TARGET IDENTIFICATION - EPITOPE

IDENTIFICATION