Syllabus For The Subject GENOMICS AND PROTEOMICS

UNIT - 01

GENOME - OVERVIEW OF GENOME; SEQUENCE OF GENOME ACQUSITION AND

ANALYSIS - HOMOLOGIES - SNPS - GENETIC ANALYSIS, LINKAGE MAPPING, HIGH

RESOLUTION CHROMOSOME MAPPING AND ANALYSIS - PHYSICAL MAPPING, YAC,

HYBRID MAPPING, STRATEGIES, SEQUENCE SPECIFIC TAGS (SST), SEQUENCE TAGGED

SITES(STS), ISH, FISH, RFLP, RAPD.

UNIT - 02

DNA SEQUENCING - MDTHODS, MAXAM AND GILBERT METHOD, LADDER,

FLOURESCENT, SHOT GUN, MASS SPECTROMETRY, AUTOMATION DEQUENCING - FIND

GENE MUTATIONS, IMPLICATIONS OF DNA - SEQUENCING AND SEQUENING GENOMES.

UNIT - 03

GENOME DATA BANK, METABOLIC PATHWAY DATA - CONSTRUCTION AND SCREENING

OF CDNA, LIBRARIES AND MICROARRAYS - PPLICATION OF DNA ARRAYS - PCR -

VARIATIONS IN PCR - GENE DISTRUPTIONS - SAGE AND SADE, PHARMACOGENOMICS.

UNIT - 04

PROTEIN SEQUENCE ANALYSIS - INTRODUCTION - SEQUENCE DATA BANKS - WBRF - PIR

- SWISSPORT - DATABASES, DATA MINING - ALGORITHMS OF PROTEOMICS AND ITS

APPLICATIONS - PROTEIN EXPRESSION PROFILLING - PROTEIN - PROTEIN INTERACTION

- PROTEIN MODIFICATIONS. AUTOMATION - NUCLEIC ACID DATA BANK - EMBL

NUCLEOTIDE SEQUENCE DATA BANK - AIDS VIRUS SEQUENCE DATA BANK - RNA DATA

BANK.

UNIT - 05

TOOLS FOR DATA BANK - PAIRWISE ALIGNMENT - NEEDLEMAN AND WUSCH ALGORIGHM

- SMITH WATERMAN - MULTIPLE ALIGNMENT - CLUSTRAL - PRAS - BLAST - FAST,

ALGORITHMS TO ANALYSE SEQUENCE DATA - PDB, CAMBRIDGE STRUCTURE DATA

BASE (LSD), 2D ELECTROPHORESIS, IEF, HPLC, PROTEIN DIGESTION TECHNIQUE, MASS

SPECTROMETRY, MALDI, TOF, PEPTIDES, MASS FINGER, PRINTING, PROTEIN.

Vinayaka Missions University,Directorate of Distance Education

Salem India

MASTER OF SCIENCE IN BIO INFORMATICS

2 Yr.

GENOMICS AND PROTEOMICS(2030902)

 

 

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